Sure, I'll assume we're using OBS (Open Broadcast Software).
So step one (after the obvious download, etc) is to set up a scene.
For our purpose, we'll probably only need one scene since we won't be streaming different games that will need to have the file name path updated constantly or set up AFK screens or the like.
-To do this we'll right click on the scenes box, click add scene and name it (40k Stream, etc).
-Next we'll need to tell OBS what sources from the computer to route to this scene IE: Webcam(s), Text Documents, PDFs for Rules referencing, Graphics, etc. This is done by right clicking on the sources box -> add -> click the source type you want to add. Let's say we wanted to add a webcam (which we surely will). We'll select Video Capture device in the drop down under sources -> add. This will let us name the source (Commentator Webcam, Player Cam 1, Player Cam 2, etc). Next a window pops up that lets us select the actual source from the computer (Device) as well as some resolution, color, video buffering and vertical/horizontal flip options. They're pretty self explanatory and, honestly, unless there are problems with the stream, leave them all default.
-We repeat this process until all the sources are routed to the scene we're building. You'll notice there will be a checkbox next to each source so you can temporarily disable them for specific streams.
-Once our scene is built, we'll need to set up OBS to broadcast to Twitch (or your stream hosting site of choice). This is under Settings -> Broadcast Settings. Mode should be Live Stream. Streaming Service should be twitch (or whatever site we're using). FMS URL is the closest hosting URL to us (Los Angeles, CA if Twitch probably). Play Path/Stream Key (if any) is where the magic happens. You'll need to get your stream key from your Twitch Dashboard and copy+paste it in here. This is how OBS plays on your specific twitch channel. The rest of that box is pretty basic - do you want to save your streams, if so, where, buffer length, etc.
-Make sure your Audio settings are appropriate (audio interface and mics are selected, Hotkeys are set up, etc
That's the jist of it. Everything else is generally left as default unless problems occur. Who is providing what gear and when are we planning on doing this or at least a systems test?